Caloric restriction (CR)—generally defined as the practice of undernutrition without malnutrition — is widely recognized as the only paradigm that has been demonstrated through extensive experimentation not only to extend life span in a variety of species, but to decelerate the onset of age-associated diseases. CR has been shown in repeated experiments to extend mean and maximum life span, decelerate the rate of aging, and inhibit the onset of a number of life-shortening diseases in laboratory animals.
An understanding of the biological mechanism involved in CR protection will provide the means of retarding chronic disease and extending maximum life span in humans. After 65 years of extensive study, however, revealing this mechanism has proven elusive, in part because researchers have been searching for the mechanism through studies designed to elucidate the process of aging itself.
Irazú applied an entirely novel approach that involved searching for an upstream metabolic trigger—a biochemical “switch”—that would turn on events at the molecular, cellular, tissue, and organ levels to induce CR-protective benefits. This biochemical trigger mechanism is precisely what IRAZÚ has discovered.